The 2023 Sir Philip Randle Lecture will be awarded to Grahame Hardie, Professor of Cellular Signalling at Dundee University. 

His group discovered that protein kinases phosphorylating and inactivating the key metabolic enzymes acetyl-CoA carboxylase (ACC) and HMG-CoA reductase were the same entity, which they renamed AMP-activated protein kinase or AMPK (the idea to pursue this arose over a couple of beers with his then mentor, Philip Cohen). AMPK is now known to have dozens of downstream targets regulating most aspects of cellular function. Grahame’s group elucidated the canonical mechanism by which AMPK is activated by energy stress, revealing it to be a critical sensor of cellular metabolic status. They identified the sites phosphorylated on ACC and AMPK, now used as universal biomarkers for AMPK activation. More recently they showed AMPK is activated by diverse non-canonical mechanisms in response to agents that increase intracellular Ca²⁺, glucose starvation or DNA damage. AMPK is now a key target for drugs with potential to treat metabolic disorders and cancer. Grahame was awarded the Rolf Luft Prize for Endocrinology and Metabolism in 2008, the Novartis Medal of the Biochemical Society in 2010, and the Solomon Berson Distinguished Lecture of the American Physiological Society in 2015.

Grahame said: “I am delighted and honoured to be selected to deliver the Sir Philip Randle lecture. I was lucky enough to meet Sir Philip on several occasions. He was a pioneer in the field of metabolic regulation that I entered, and he was one of the few biochemists that I looked up to both metaphorically and literally (I was 6 feet 6, but he was even taller)!”

The 2023 Sir Philip Randle Lecture will be awarded to Guy Rutter. Guy is a principal research fellow at the Research Centre CHUM, University of Montreal, Professor of Cell Biology at Imperial College London and Visiting Professor at Nanyang Technological College, Singapore.

Professor Rutter undertook a PhD on the hormonal control of mitochondrial metabolism with Prof Dick Denton FRS in the Department of Biochemistry first established by Sir Philip Randle at Bristol University, U.K. He then won an MRC Travelling Fellowship to study insulin secretion under Claes Wollheim in Geneva, in collaboration with Tullio Pozzan and Rosario Rizzuto in Padua. He returned to Bristol in 1993, moved to Imperial in 2006 to establish the Section of Cell Biology, and joined the University of Montreal in Canada in 2021.

His current research focusses on diabetes mellitus, a condition which currently affects almost 10 % of the adult population worldwide. His chief goals are to develop new means to enhance insulin secretion in Type 2 diabetes by studying the fundamental signalling pathways through which glucose, incretins and other hormones act on the pancreatic β cell. He deploys knowledge flowing from genome-wide and other genetic studies for this disease, and state-of-the-art technologies ranging from mouse models through genome editing, electrophysiology, super-resolution imaging, optogenetics, transcriptomics and proteomics.

Guy said: “This award means a lot to me, having known Sir Philip personally, and studied under one of his own students (Denton)!  I’m also pleased that the lecture will allow me to present some of our work on insulin secretion, an area in which Sir Philip made important contributions.”

The 2019 Sir Philip Randle Lecture was awarded to Antonio Vidal-Puig from the Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK. Antonio’s research focuses on elucidating the molecular mechanisms linking obesity with insulin resistance, diabetes and cardiometabolic complications and on the development of related therapeutic strategies. His research strategies include a combination of hypothesis driven and non-biased systems approaches that make extensive use of animal models, stem cell biology, human biological samples (including induced pluripotent stem cells), sophisticated omics technologies and bioinformatics integration. Vidal-Puig’s lab creativity is reflected in the “adipose tissue expandability hypothesis” and the concept of “lipotoxicity” to explain the association between obesity and cardiometabolic complications. His specific scientific contributions to four lines of research are: 1. defining the adipose tissue expandability and lipotoxicity hypothesis and the relevance of adipose tissue macrophages mediating adipose tissue inflammation; 2. proposing the use of energy dissipating strategies to reverse lipotoxicity by promoting mitochondrial biogenesis, mitochondrial uncoupling and brown fat differentiation and activation; 3. establishing the relevance of hypothalamic lipid metabolism in controlling energy homeostasis and thyroid hormone and BMP8b controlling brown fat activation and 4. the pioneering use of systems biology and stem cell approaches to elucidate the role of specific lipids and networks in the development the cardiometabolic syndrome. 

Of winning the Sir Philip Randle Lecture, Antonio said “I am delighted with this award that recognises the excellent work of the members of my laboratory over the years”.

Antonio presented his award lecture at the Biochemical Society and World Obesity Federation joint conference ‘Maternal obesity and pre-eclampsia: common pathways’ on 5-6 November 2019 in Amsterdam, The Netherlands.

The 2017 Sir Philip Randle Lecture was awarded to Geoffrey D Holman from University of Bath. Geoffrey has made a major contribution to the field of insulin regulated glucose metabolism, principally the mechanism by which glucose enters cells in response to insulin stimulation through a regulated transporter translocation mechanism. His work has direct impact on our understanding of human insulin-resistant state and the development of Type 2 Diabetes. 

Read Geoffrey's article published in the Biochemical Journal - Chemical biology probes of mammalian GLUT structure and function. 

Geoffrey presented his award lecture at the Society conference entitled ‘Insulin and exercise signalling for glucose homeostasis and metabolic health‘ on 6-8 September 2017 at the University of Bath, UK.